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phospho acc ser 79 rabbit mab  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc phospho acc ser 79 rabbit mab
    ( A ) Western blot analysis of female mouse livers fed HFD containing doxycycline (Doxy) to express constitutive active AMPK [a1(1-312); AMPK CA ] for 7 days compared to control livers. ( B ) Immunohistochemical analysis of livers from male control and AMPK CA mice fed HFD+Doxy for 7 months. Scale bars, 100 μm. Right: Quantification of the staining intensity for P-Thr 172 AMPK and P-Ser 79 ACC staining. n = 6 to 10. ±SEM, Welch t test. ( C ) Representative whole-mount (top) and MRI (bottom) image of male control and AMPK CA livers 9 months post–DEN injection. Yellow dashed lines indicate tumors. ( D ) Quantification of the tumor number in male control and AMPK CA livers 6 and 9 months post–DEN injection based on MRI images. 6 months: N = 5 to 7; 9 months: N = 16 to 17; Fisher least significant difference (LSD) test. ( E ) Quantification of the serum AFP levels in control and AMPK CA male mice 6 and 9 months post–DEN injection. n = 9 to 15. Fisher LSD test. * P < 0.05; *** P < 0.001; **** P < 0.0001.
    Phospho Acc Ser 79 Rabbit Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho+acc/pmc13068069-9-0-7
    Average 86 stars, based on 1 article reviews
    phospho acc ser 79 rabbit mab - by Bioz Stars, 2026-09
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    Images

    1) Product Images from "Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity"

    Article Title: Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity

    Journal: Science Advances

    doi: 10.1126/sciadv.aea8017

    ( A ) Western blot analysis of female mouse livers fed HFD containing doxycycline (Doxy) to express constitutive active AMPK [a1(1-312); AMPK CA ] for 7 days compared to control livers. ( B ) Immunohistochemical analysis of livers from male control and AMPK CA mice fed HFD+Doxy for 7 months. Scale bars, 100 μm. Right: Quantification of the staining intensity for P-Thr 172 AMPK and P-Ser 79 ACC staining. n = 6 to 10. ±SEM, Welch t test. ( C ) Representative whole-mount (top) and MRI (bottom) image of male control and AMPK CA livers 9 months post–DEN injection. Yellow dashed lines indicate tumors. ( D ) Quantification of the tumor number in male control and AMPK CA livers 6 and 9 months post–DEN injection based on MRI images. 6 months: N = 5 to 7; 9 months: N = 16 to 17; Fisher least significant difference (LSD) test. ( E ) Quantification of the serum AFP levels in control and AMPK CA male mice 6 and 9 months post–DEN injection. n = 9 to 15. Fisher LSD test. * P < 0.05; *** P < 0.001; **** P < 0.0001.
    Figure Legend Snippet: ( A ) Western blot analysis of female mouse livers fed HFD containing doxycycline (Doxy) to express constitutive active AMPK [a1(1-312); AMPK CA ] for 7 days compared to control livers. ( B ) Immunohistochemical analysis of livers from male control and AMPK CA mice fed HFD+Doxy for 7 months. Scale bars, 100 μm. Right: Quantification of the staining intensity for P-Thr 172 AMPK and P-Ser 79 ACC staining. n = 6 to 10. ±SEM, Welch t test. ( C ) Representative whole-mount (top) and MRI (bottom) image of male control and AMPK CA livers 9 months post–DEN injection. Yellow dashed lines indicate tumors. ( D ) Quantification of the tumor number in male control and AMPK CA livers 6 and 9 months post–DEN injection based on MRI images. 6 months: N = 5 to 7; 9 months: N = 16 to 17; Fisher least significant difference (LSD) test. ( E ) Quantification of the serum AFP levels in control and AMPK CA male mice 6 and 9 months post–DEN injection. n = 9 to 15. Fisher LSD test. * P < 0.05; *** P < 0.001; **** P < 0.0001.

    Techniques Used: Western Blot, Control, Immunohistochemical staining, Staining, Injection

    ( A ) Quantification of the tumor size from MRI imaging at 6 and 9 months. n = 10 to 448. Log normal Welch t test. ( B ) Immunohistochemical analysis of BrdU incorporation in tumor tissue from control and AMPK CA livers following a 4-hour BrdU pulse (10 mg/kg). Scale bars, 100 μm. Right: Quantification of the number of positive cells per area. n = 13 to 17. Welch t test. ( C ) Gene expression of Ampka1 normalized to Actin in nontumor and tumor tissue. n = 5 to 6. ±SEM, Fisher LSD test. ( D ) Immunohistochemical analysis of P-Ser 79 ACC in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( E ) Quantification of the staining intensity of P-Ser 79 ACC. n = 5 to 14. Fisher LSD test. ( F ) Immunohistochemical analysis of P-Thr 172 AMPK in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( G ) Quantification of the staining intensity. n = 6 to 11. Fisher LSD test. ( H ) Western blot analysis of nontumor (NT) and tumor (T) tissue. VINCULIN as loading control. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001.
    Figure Legend Snippet: ( A ) Quantification of the tumor size from MRI imaging at 6 and 9 months. n = 10 to 448. Log normal Welch t test. ( B ) Immunohistochemical analysis of BrdU incorporation in tumor tissue from control and AMPK CA livers following a 4-hour BrdU pulse (10 mg/kg). Scale bars, 100 μm. Right: Quantification of the number of positive cells per area. n = 13 to 17. Welch t test. ( C ) Gene expression of Ampka1 normalized to Actin in nontumor and tumor tissue. n = 5 to 6. ±SEM, Fisher LSD test. ( D ) Immunohistochemical analysis of P-Ser 79 ACC in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( E ) Quantification of the staining intensity of P-Ser 79 ACC. n = 5 to 14. Fisher LSD test. ( F ) Immunohistochemical analysis of P-Thr 172 AMPK in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( G ) Quantification of the staining intensity. n = 6 to 11. Fisher LSD test. ( H ) Western blot analysis of nontumor (NT) and tumor (T) tissue. VINCULIN as loading control. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001.

    Techniques Used: Imaging, Immunohistochemical staining, BrdU Incorporation Assay, Control, Gene Expression, Staining, Western Blot

    Related Articles

    Membrane:

    Article Title: Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle.
    Article Snippet: .. Membranes were probed with the following primary antibodies at a 1:1000 dilution: targeting phospho- Ampkα (T172) (CST, #2535), Ampk α (CST, #2532), phospho- ACC (CST, #3661), phospho- ULK1(CST, #5869), ULK1 (Sigma- Aldrich, #A7481), α- tubulin (Abcam, Cambridge, MA, USA, #ab11304), glyceraldehyde- 3- phosphate dehydrogenase (CST, #2118) and normalized to a muscle common standard loaded in the middle of the membrane. ..

    Article Title: Ghardaqenoids A-F: Six New Diterpenoids from the South China Sea Soft Coral Heteroxenia ghardaqensis with Lipid-Lowering Activity via the Activation of the AMPK Signaling Pathway.
    Article Snippet: .. The membrane was then incubated overnight at 4 ◦C with diluted primary antibodies on a shaker, including phospho-AMPK (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), AMPK (Starter, Hangzhou, China, 1:1000 dilution), phospho-ACC (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), ACC (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), SREBP-1 (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), and GAPDH (Yeasen Biotechnology, Shanghai, China, 1:1000 dilution). ..

    Article Title: Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle
    Article Snippet: .. Membranes were probed with the following primary antibodies at a 1:1000 dilution: targeting phospho-Ampkα (T172) (CST, #2535), Ampk α (CST, #2532), phospho-ACC (CST, #3661), phospho-ULK1(CST, #5869), ULK1 (Sigma-Aldrich, #A7481), α-tubulin (Abcam, Cambridge, MA, USA, #ab11304), glyceraldehyde-3-phosphate dehydrogenase (CST, #2118) and normalized to a muscle common standard loaded in the middle of the membrane. ..

    Cell-Signaling:

    Article Title: Acute Cold Exposure Cell-Autonomously Reduces mTORC1 Signaling and Protein Synthesis Independent of AMPK.
    Article Snippet: .. Primary antibodies [Puromycin (Millipore MABE343, Bedford, MA, USA), phospho-ACC (Cell Signaling #3661, Danvers, MA, USA), ACC (Cell Signaling #3676), phospho-S6K (Cell Signaling #9234), S6K (Cell Signaling #2708), phospho-S6 (Cell Signaling #4858), S6 (Cell Signaling #2217)] were applied for either 4 h at room temperature or overnight at 4 ◦C. .. Membranes were then incubated in near-infrared fluorescent secondary antibodies [anti-mouse (Jackson Immunoresearch #115-625-174, West Grove, PA, USA) or anti-rabbit (ThermoFisher #SA535571, Waltham, MA, USA)] for 1 h at room temperature.

    Incubation:

    Article Title: Ghardaqenoids A-F: Six New Diterpenoids from the South China Sea Soft Coral Heteroxenia ghardaqensis with Lipid-Lowering Activity via the Activation of the AMPK Signaling Pathway.
    Article Snippet: .. The membrane was then incubated overnight at 4 ◦C with diluted primary antibodies on a shaker, including phospho-AMPK (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), AMPK (Starter, Hangzhou, China, 1:1000 dilution), phospho-ACC (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), ACC (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), SREBP-1 (Cell Signaling Technology, Boston, MA, USA, 1:1000 dilution), and GAPDH (Yeasen Biotechnology, Shanghai, China, 1:1000 dilution). ..

    Article Title: Distinct immunometabolic signatures of type 1 versus type 2 diabetes in a murine model of myocardial infarction.
    Article Snippet: Total protein was quantified using the PierceTM Reversible Protein Stain Kit (Thermo Scientific). .. Membranes were then blocked for 1 hr (SuperBlockTM Blocking Buffer, Thermo Scientific), and incubated with primary antibodies against PDH (1:1000; CST #3205S), phospho-PDH (Serine 293; 1:1000; CST #31866S), phospho-Akt (serine 473; 1:1000; Cell Signaling Technologies #9271), Akt (1:1000; CST #9272), phospho-ACC (serine 79; 1:1000; CST #D7D11), and ACC (1:1000; CST #3676). .. Membranes were then incubated with a secondary antibody (IRDye® 8000CW Donkey Anti-Rabbit IgG; 1:10,000; Li-Cor) for 2hr at room temperature, and blot were imaged using the Odyssey CLx Imaging System.

    Article Title: Distinct immunometabolic signatures of type 1 versus type 2 diabetes in a murine model of myocardial infarction
    Article Snippet: Total protein was quantified using the PierceTM Reversible Protein Stain Kit (Thermo Scientific). .. Membranes were then blocked for 1 h (SuperBlockTM Blocking Buffer, Thermo Scientific), and incubated with primary antibodies against PDH (1:1000; CST #3205S), phospho-PDH (Serine 293; 1:1000; CST #31866S), phospho-Akt (serine 473; 1:1000; Cell Signaling Technologies #9271), Akt (1:1000; CST #9272), phospho-ACC (serine 79; 1:1000; CST #D7D11), and ACC (1:1000; CST #3676). .. Membranes were then incubated with a secondary antibody (IRDye ® 8000CW Donkey Anti-Rabbit IgG; 1:10,000; Li-Cor) for 2 h at room temperature, and blot were imaged using the Odyssey CLx Imaging System.

    other:

    Article Title: Microencapsulated fermented wild blueberries attenuate diet-induced lipid dysmetabolism
    Article Snippet: Next, membranes were incubated for 1 h at room temperature with the corresponding Horseradish peroxidase (HRP)-conjugated immunoglobulin G (IgG) secondary antibody (Mouse immunoglobulin G (IgG) (7074) (Cell Signaling Technologies, Danvers, MA, USA) at 1:2,000 (v/v) ratio dilution).

    Blocking Assay:

    Article Title: Distinct immunometabolic signatures of type 1 versus type 2 diabetes in a murine model of myocardial infarction.
    Article Snippet: Total protein was quantified using the PierceTM Reversible Protein Stain Kit (Thermo Scientific). .. Membranes were then blocked for 1 hr (SuperBlockTM Blocking Buffer, Thermo Scientific), and incubated with primary antibodies against PDH (1:1000; CST #3205S), phospho-PDH (Serine 293; 1:1000; CST #31866S), phospho-Akt (serine 473; 1:1000; Cell Signaling Technologies #9271), Akt (1:1000; CST #9272), phospho-ACC (serine 79; 1:1000; CST #D7D11), and ACC (1:1000; CST #3676). .. Membranes were then incubated with a secondary antibody (IRDye® 8000CW Donkey Anti-Rabbit IgG; 1:10,000; Li-Cor) for 2hr at room temperature, and blot were imaged using the Odyssey CLx Imaging System.

    Article Title: Distinct immunometabolic signatures of type 1 versus type 2 diabetes in a murine model of myocardial infarction
    Article Snippet: Total protein was quantified using the PierceTM Reversible Protein Stain Kit (Thermo Scientific). .. Membranes were then blocked for 1 h (SuperBlockTM Blocking Buffer, Thermo Scientific), and incubated with primary antibodies against PDH (1:1000; CST #3205S), phospho-PDH (Serine 293; 1:1000; CST #31866S), phospho-Akt (serine 473; 1:1000; Cell Signaling Technologies #9271), Akt (1:1000; CST #9272), phospho-ACC (serine 79; 1:1000; CST #D7D11), and ACC (1:1000; CST #3676). .. Membranes were then incubated with a secondary antibody (IRDye ® 8000CW Donkey Anti-Rabbit IgG; 1:10,000; Li-Cor) for 2 h at room temperature, and blot were imaged using the Odyssey CLx Imaging System.



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    Image Search Results


    ( A ) Western blot analysis of female mouse livers fed HFD containing doxycycline (Doxy) to express constitutive active AMPK [a1(1-312); AMPK CA ] for 7 days compared to control livers. ( B ) Immunohistochemical analysis of livers from male control and AMPK CA mice fed HFD+Doxy for 7 months. Scale bars, 100 μm. Right: Quantification of the staining intensity for P-Thr 172 AMPK and P-Ser 79 ACC staining. n = 6 to 10. ±SEM, Welch t test. ( C ) Representative whole-mount (top) and MRI (bottom) image of male control and AMPK CA livers 9 months post–DEN injection. Yellow dashed lines indicate tumors. ( D ) Quantification of the tumor number in male control and AMPK CA livers 6 and 9 months post–DEN injection based on MRI images. 6 months: N = 5 to 7; 9 months: N = 16 to 17; Fisher least significant difference (LSD) test. ( E ) Quantification of the serum AFP levels in control and AMPK CA male mice 6 and 9 months post–DEN injection. n = 9 to 15. Fisher LSD test. * P < 0.05; *** P < 0.001; **** P < 0.0001.

    Journal: Science Advances

    Article Title: Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity

    doi: 10.1126/sciadv.aea8017

    Figure Lengend Snippet: ( A ) Western blot analysis of female mouse livers fed HFD containing doxycycline (Doxy) to express constitutive active AMPK [a1(1-312); AMPK CA ] for 7 days compared to control livers. ( B ) Immunohistochemical analysis of livers from male control and AMPK CA mice fed HFD+Doxy for 7 months. Scale bars, 100 μm. Right: Quantification of the staining intensity for P-Thr 172 AMPK and P-Ser 79 ACC staining. n = 6 to 10. ±SEM, Welch t test. ( C ) Representative whole-mount (top) and MRI (bottom) image of male control and AMPK CA livers 9 months post–DEN injection. Yellow dashed lines indicate tumors. ( D ) Quantification of the tumor number in male control and AMPK CA livers 6 and 9 months post–DEN injection based on MRI images. 6 months: N = 5 to 7; 9 months: N = 16 to 17; Fisher least significant difference (LSD) test. ( E ) Quantification of the serum AFP levels in control and AMPK CA male mice 6 and 9 months post–DEN injection. n = 9 to 15. Fisher LSD test. * P < 0.05; *** P < 0.001; **** P < 0.0001.

    Article Snippet: Phospho-ACC (Ser 79 ) Rabbit mAb , Cell Signaling Technology , 11818.

    Techniques: Western Blot, Control, Immunohistochemical staining, Staining, Injection

    ( A ) Quantification of the tumor size from MRI imaging at 6 and 9 months. n = 10 to 448. Log normal Welch t test. ( B ) Immunohistochemical analysis of BrdU incorporation in tumor tissue from control and AMPK CA livers following a 4-hour BrdU pulse (10 mg/kg). Scale bars, 100 μm. Right: Quantification of the number of positive cells per area. n = 13 to 17. Welch t test. ( C ) Gene expression of Ampka1 normalized to Actin in nontumor and tumor tissue. n = 5 to 6. ±SEM, Fisher LSD test. ( D ) Immunohistochemical analysis of P-Ser 79 ACC in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( E ) Quantification of the staining intensity of P-Ser 79 ACC. n = 5 to 14. Fisher LSD test. ( F ) Immunohistochemical analysis of P-Thr 172 AMPK in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( G ) Quantification of the staining intensity. n = 6 to 11. Fisher LSD test. ( H ) Western blot analysis of nontumor (NT) and tumor (T) tissue. VINCULIN as loading control. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001.

    Journal: Science Advances

    Article Title: Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity

    doi: 10.1126/sciadv.aea8017

    Figure Lengend Snippet: ( A ) Quantification of the tumor size from MRI imaging at 6 and 9 months. n = 10 to 448. Log normal Welch t test. ( B ) Immunohistochemical analysis of BrdU incorporation in tumor tissue from control and AMPK CA livers following a 4-hour BrdU pulse (10 mg/kg). Scale bars, 100 μm. Right: Quantification of the number of positive cells per area. n = 13 to 17. Welch t test. ( C ) Gene expression of Ampka1 normalized to Actin in nontumor and tumor tissue. n = 5 to 6. ±SEM, Fisher LSD test. ( D ) Immunohistochemical analysis of P-Ser 79 ACC in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( E ) Quantification of the staining intensity of P-Ser 79 ACC. n = 5 to 14. Fisher LSD test. ( F ) Immunohistochemical analysis of P-Thr 172 AMPK in nontumor and tumor tissue from control and AMPK CA livers. Scale bars, 100 μm. ( G ) Quantification of the staining intensity. n = 6 to 11. Fisher LSD test. ( H ) Western blot analysis of nontumor (NT) and tumor (T) tissue. VINCULIN as loading control. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001.

    Article Snippet: Phospho-ACC (Ser 79 ) Rabbit mAb , Cell Signaling Technology , 11818.

    Techniques: Imaging, Immunohistochemical staining, BrdU Incorporation Assay, Control, Gene Expression, Staining, Western Blot